ISSN 2687-0568

Hyaluronic Acid as Object of Analysis and Accessory Material for X-Ray and Laser Science: a Review

Authors
P.P. Snetkov 1 , R.O. Shaikenov 1 , P.G. Serbun 1 , H. Wu 1, 2 , D.A. Bauman 1 , Z. Wang 2 , S.N. Morozkina 1

1 Institute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy pr., 49, bldg. A, St. Petersburg, 197101, Russia

2 International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, 7089 Weixing Road, Changchun, 130022, China

Rev. Adv. Mater. Technol., 2024, vol. 6, no. 2, pp. 67–79
Abstract

Modern medicine greatly needs high-effective and safe medications and diagnostic agents. Encapsulation of pharmaceutical agents having low water solubility and lipophilicity into biopolymer matrixes allows to increase the bioavailability of such systems. Hyaluronic acid is one of the most suitable polymer for this purpose. However, in spite of the large amount of drug delivery systems based on it, the structure of such systems is unknown, which hinder the development of high effective therapeutic medication and, as a result, the transition toward personalized medicine. X-ray, laser and synchrotron techniques could help us to understand the interaction between the drug and polymer matrix, that allow to further extend for another biological molecules. This review aims to discuss current status of the previous investigations of materials based on hyaluronic acid via X-ray, laser and synchrotron methods of analysis. Moreover, key information related to hyaluronic acid is provided.

Keywords
Hyaluronic acid; Synchrotron radiation; X-ray; Modern drug delivery systems
Foundings

Ministry of Science and Higher Education of the Russian Federation: 075-15-2021-1349

References
Volume 6, No 2
pages 67-79
History
© 2024 ITMO University.
This is an open access article under the terms
of the CC BY-NC 4.0 license.
Metadata is available under the terms of the CC BY 4.0 license